反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[H-].[Na+].Cl[C:15]1[CH:20]=[C:19]([N:21]([CH3:23])[CH3:22])[CH:18]=[C:17]([O:24][CH2:25][C:26]2[CH:30]=[CH:29][S:28][CH:27]=2)[N:16]=1>CN(C)C(=O)C.[Cu]I>[CH3:22][N:21]([CH3:23])[C:19]1[CH:20]=[C:15]([O:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=2)[N:16]=[C:17]([O:24][CH2:25][C:26]2[CH:30]=[CH:29][S:28][CH:27]=2)[CH:18]=1参加物
6
反応物 3
生成物 1
試薬・触媒・溶媒 2
実験手順
To a solution of meta-trifluoromethylphenol (1.27 g, 0.0020×4.0 mol) in 20 ml of dry N,N-dimethylacetamide, sodium hydride (0.313 g, (ca.60% in mineral oil), 0.0020×4.0 mol) was added. After the bubbling ceased, a solution of 2-chloro-4-dimethylamino-6-(3-thienylmethyloxy)pyridine (0.526 g, 0.0020 mol) in 20 ml of dry N,N-dimethylacetamide was added dropwise, then CuI (0.186 g, 0.0020×0.5 mol) was added thereto and the resultant solution was stirred for 24 hours at the temperature of 170° to 180° C.
出典と根拠
- ORDレコード
- ord-9d8ce96f1e2f4bf88603a54003fce961
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05624942
関連ノート
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