Water → HCID 72702564、化合物

HRID 551780ノート

反応式

HRID 551780 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[C:13](=O)[CH2:14][NH:15][C:16](=[O:18])[CH3:17])=[CH:5][CH:4]=1.Cl.[NH2:21][OH:22].N1C=CC=CC=1.O>CO>[OH:22]/[N:21]=[C:13](/[C:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=2)[CH:7]=[CH:8][CH:9]=1)\[CH2:14][NH:15][C:16](=[O:18])[CH3:17]

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 44541672N-[2-(7-Methoxy-1-naphthyl)-2-oxoethyl]acetamide

生成物 1

HCID 72702564HCID 72702564、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a 100-ml round-bottom flask, the compound obtained in Step G (4.2 mmol) is dissolved in 25 ml of methanol. Hydroxylamine hydrochloride (16.8 mmol) and pyridine (21.1 mmol) are added and then the reaction mixture is heated at reflux, with magnetic stirring, for 3 hours. After cooling, the reaction mixture is poured into 50 ml of water. The precipitate formed is filtered off under suction, washed with water and recrystallised from toluene to yield the title product in the form of a white solid.

後処理

  1. temperaturethe reaction mixture is heated
  2. temperatureat reflux, with magnetic stirring, for 3 hours
  3. temperatureAfter cooling
  4. customThe precipitate formed
  5. filtrationis filtered off under suction
  6. washwashed with water
  7. customrecrystallised from toluene

出典と根拠

ORDレコード
ord-8dac76ab604f4edaa3ff083e43e822ab
出典データセット
uspto-grants-2011_05
特許番号
US07947852B2

反応ノート

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