Lithium Hydroxide → 5-Methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoic acid

HRID 552685ノート

反応式

HRID 552685 の反応式
C[O:2][C:3](=[O:20])[C:4]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:5]=1[N:14]1[CH:18]=[C:17]([CH3:19])[CH:16]=[N:15]1.[OH-].[Li+]>C1COCC1.O>[CH3:13][S:10]([C:8]1[CH:7]=[CH:6][C:5]([N:14]2[CH:18]=[C:17]([CH3:19])[CH:16]=[N:15]2)=[C:4]([CH:9]=1)[C:3]([OH:20])=[O:2])(=[O:11])=[O:12]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 577533435-Methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoic acid methyl ester

生成物 1

HCID 577533765-Methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To 2.08 mmol 5-Methanesulfonyl-2-(4-methyl-pyrazol-1-yl)-benzoic acid methyl ester in 2.2 ml THF and 2.2 ml water was added 3.12 mmol lithium hydroxide and the reaction mixture was stirred at RT for 2 hours. After such time the solvent was removed in vacuo, the residue was taken in water and acidified by addition of 3N HCl to yield after filtration the title compound as a white solid (88%). MS (m/e): 279.1 ([M−H], 100%).

後処理

  1. customAfter such time the solvent was removed in vacuo
  2. additionacidified by addition of 3N HCl
  3. customto yield
  4. filtrationafter filtration the title compound as a white solid (88%)

出典と根拠

ORDレコード
ord-84fe7bcddf0547fe8f034216b4a28b3b
出典データセット
uspto-grants-2011_05
特許番号
US07951836B2

反応ノート

読み込み中…