反応式
[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8](I)[N:7]=1.[CH2:15]([OH:20])[CH2:16][CH2:17][C:18]#[CH:19]>>[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]([C:19]#[C:18][CH2:17][CH2:16][CH2:15][OH:20])[N:7]=1参加物
3
実験手順
Under the conditions of example 5 A, 5 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 1.37 g of 4-pentyn-1-ol, worked up, and the crude product is chromatographed on silica gel with hexane/0-4% methanol. 1.2 g of 3-[3-hydroxy-6-(5-hydroxy-1-pentynyl)-2-pyridyl]-propionic acid methyl ester is obtained as colorless oil.
後処理
- customthe crude product is chromatographed on silica gel with hexane/0-4% methanol
出典と根拠
- ORDレコード
- ord-3041615f29b8409b826be1c81f949e26
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05624943
関連ノート
読み込み中…