Hydrochloric Acid → (5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid

HRID 554609ノート

反応式

HRID 554609 の反応式
C[O:2][C:3](=[O:30])[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[CH2:21][N:22]([C:25]([CH:27]2[CH2:29][CH2:28]2)=[O:26])[CH2:23][CH3:24])[CH:10]=1.CO.[OH-].[Na+].Cl>C1COCC1>[CH:27]1([C:25]([N:22]([CH2:21][C:12]2[CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=[CH:16][C:11]=2[C:9]2[CH:10]=[C:5]([CH2:4][C:3]([OH:30])=[O:2])[CH:6]=[N:7][CH:8]=2)[CH2:23][CH3:24])=[O:26])[CH2:29][CH2:28]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 67212307HCID 67212307、化合物

生成物 1

HCID 45138480(5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(5-{2-[(N-Cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid methyl ester (0.069 g, 0.16 mmol) was dissolved in THF (1 mL) and MeOH (0.8 mL) and treated with 1N aqueous NaOH (0.5 mL). The reaction was stirred at room temperature for 1 hour. The mixture was neutralized with 1N aqueous HCl and extracted twice with CH2Cl2. The combined organic layers were dried over MgSO4, filtered, and concentrated to give Compound 8.

後処理

  1. extractionextracted twice with CH2Cl2
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-0bbe70d1583b4319a8a51bc85945ffb3
出典データセット
uspto-grants-2011_11
特許番号
US08049015B2

反応ノート

読み込み中…