Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 67459847、化合物
反応式
[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]=O)[N:6]=1.[CH3:9][O:10][C:11](=[O:32])[CH:12]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>O1CCCC1.O>[CH3:9][O:10][C:11](=[O:32])[CH:12]=[CH:7][C:5]1[N:6]=[C:2]([Br:1])[S:3][CH:4]=1参加物
5
実験手順
Dissolve 2-bromothiazole-4-carbaldehyde (3.00 g, 15.62 mmol) in tetrahydrofuran (52 mL) and add methyl(triphenylphosphoranylidene)acetate (5.33 g. 15.62 mmol). Stir the mixture overnight at room temperature. Dilute the mixture with water and extract twice using diethyl ether. Dry the combined organics over sodium sulfate, filter, and concentrate. Purify via silica gel chromatography using a 0-30% gradient of EtOAc/hexanes to give 3.13 g (81%) of the title compound as a white solid.
後処理
- extractionextract twice using diethyl ether
- dry with materialDry the combined organics over sodium sulfate
- filtrationfilter
- concentrationconcentrate
- customPurify via silica gel chromatography
出典と根拠
- ORDレコード
- ord-16f76a513b1c41c283f69bb220b0c352
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08049013B2
反応ノート
読み込み中…