Nitric Acid → 2-Amino-5-bromo-3-nitropyridine

HRID 55500

反応式

HRID 55500 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[N+:9]([O-])([OH:11])=[O:10].[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:1][C:2]1[C:7]([N+:9]([O-:11])=[O:10])=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 706222-Amino-5-bromopyridine

生成物 1

HCID 1388782-Amino-5-bromo-3-nitropyridine

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
60 °C

実験手順

100 ml of concentrated sulfuric acid were added to 25.0 g of 2-amino-5-bromopyridine, and 8.9 ml of concentrated nitric acid were then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour. The mixture was then stirred at 60° C. for 30 minutes. At the end of this time, the reaction mixture was poured into ice-water and neutralized by the addition of an aqueous solution of sodium hydroxide. The crystals which precipitated were collected by filtration and washed with ethanol, to give 19.1 g of the title compound, melting at 180°-182° C.

後処理

  1. additionwere then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. washwashed with ethanol

出典と根拠

ORDレコード
ord-38508c88984e462da47b150b81e5377a
出典データセット
uspto-grants-1997_04
特許番号
US05624935

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