Nitric Acid → 2-Amino-5-bromo-3-nitropyridine
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[N+:9]([O-])([OH:11])=[O:10].[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:1][C:2]1[C:7]([N+:9]([O-:11])=[O:10])=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1参加物
5
反応条件
- 温度
- 60 °C
実験手順
100 ml of concentrated sulfuric acid were added to 25.0 g of 2-amino-5-bromopyridine, and 8.9 ml of concentrated nitric acid were then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour. The mixture was then stirred at 60° C. for 30 minutes. At the end of this time, the reaction mixture was poured into ice-water and neutralized by the addition of an aqueous solution of sodium hydroxide. The crystals which precipitated were collected by filtration and washed with ethanol, to give 19.1 g of the title compound, melting at 180°-182° C.
後処理
- additionwere then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour
- customThe crystals which precipitated
- filtrationwere collected by filtration
- washwashed with ethanol
出典と根拠
- ORDレコード
- ord-38508c88984e462da47b150b81e5377a
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05624935
反応ノート
読み込み中…