Potassium Carbonate → [4-(2-Imidazol-1-yl-ethyl)-piperazin-1-yl]acetonitrile

HRID 555730ノート

反応式

HRID 555730 の反応式
[N:1]1([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=[CH:2]1.Br[CH2:15][C:16]#[N:17].C([O-])([O-])=O.[K+].[K+]>CC#N>[N:1]1([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][N:11]([CH2:15][C:16]#[N:17])[CH2:12][CH2:13]2)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 11534BromoacetonitrileHCID 27593491-(2-Imidazol-1-yl-ethyl)-piperazine

生成物 1

HCID 86641785[4-(2-Imidazol-1-yl-ethyl)-piperazin-1-yl]acetonitrile

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 1-(2-Imidazol-1-yl-ethyl)-piperazine (commercially available from CHESS GmbH) (1.0 g, 5.44 mmol), bromoacetonitrile (740 mg, 6.0 mmol) and K2CO3 (1.65 g, 12.0 mmol) in CH3CN (15 mL) is stirred at RT. After completion the product is isolated by filtration with Celite and washed with CH3CN and dried under reduced pressure to give the title compound as oil; ES-MS: M+H=220.2: CtRet=1.70.

後処理

  1. customAfter completion the product is isolated by filtration with Celite
  2. washwashed with CH3CN
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-5e63030a66e846a797aa9808e31403b4
出典データセット
uspto-grants-2011_11
特許番号
US08053457B2

反応ノート

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