1,3-Dibromopropane → N-[3-(3-Bromo-propoxy)-phenyl]-acetamide
反応式
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[Br:18][CH2:19][CH2:20][CH2:21]Br>ClCCl>[C:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][CH:10]=1)[O:11][CH2:21][CH2:20][CH2:19][Br:18])(=[O:3])[CH3:2]参加物
5
実験手順
To 3-acetamidophenol (15.1 g) in dichloromethane (500 ml, dry) was added potassium carbonate (20 g) and then 1,3-dibromopropane (30 g). The resulting mixture was heated at reflux for 6 hours and then overnight at room temperature. After an additional 24 hours, the reaction was complete. Solids were filtered from the reaction mixture, and the solution was concentrated to an oil, which was purified to yield 3-(3-acetamidophenoxy)propyl bromide, 13.2 g.
後処理
- temperatureThe resulting mixture was heated
- temperatureat reflux for 6 hours
- customovernight
- customat room temperature
- filtrationSolids were filtered from the reaction mixture
- concentrationthe solution was concentrated to an oil, which
- customwas purified
出典と根拠
- ORDレコード
- ord-1cd804972d384cae9a5d08e029bf40a5
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05624927
反応ノート
読み込み中…