Pyridine → 1,8-Bis[3-(diethylamino) propionamido]anthraquinone

反応式

Cl[CH2:2][CH2:3][C:4]([NH:6][C:7]1[C:20]2[C:19](=[O:21])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[NH:22][C:23](=[O:27])[CH2:24][CH2:25]Cl)[C:12](=[O:28])[C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:5].[N:29]1[CH:34]=[CH:33]C=[CH:31][CH:30]=1.[CH2:35]([NH:37][CH2:38][CH3:39])[CH3:36]>C1COCC1>[CH2:34]([N:29]([CH2:30][CH3:31])[CH2:2][CH2:3][C:4]([NH:6][C:7]1[C:20]2[C:19](=[O:21])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[NH:22][C:23](=[O:27])[CH2:24][CH2:25][N:37]([CH2:38][CH3:39])[CH2:35][CH3:36])[C:12](=[O:28])[C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:5])[CH3:33]

参加物

実験手順

Add 1,8-Bis(3-chloropropionamido)anthraquinone (compound 4, 0.42 g, 1.0 mmol) with pyridine (0.5 ml) and diethylamine (0.6 ml, 6 mmole), dissolved in 20 ml dehydrated THF. The mixture is reacted in a mini-reactor. The reaction temperature is 70-80° C. in an oil bath and the reaction time is 6 hours. The reacted mixture is poured into 50 ml ice water, extracted with ethyl acetate and recrystallized from ethanol to get yellow orange compound 4a.