Water → 2,2,2-trifluoro-N-(6-fluoro-3-iodoimidazo[1,2-a]pyridin-2-yl)acetamide

HRID 556329ノート

反応式

HRID 556329 の反応式
[F:1][C:2]([F:17])([F:16])[C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][N:9]2[CH:15]=1)=[O:4].[I:18]N1C(=O)CCC1=O.O>C(#N)C>[F:17][C:2]([F:16])([F:1])[C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][N:9]2[C:15]=1[I:18])=[O:4]

参加物

5

反応物 3

HCID 962WaterHCID 120273N-IodosuccinimideHCID 251966492,2,2-Trifluoro-N-(6-fluoroimidazo[1,2-a]pyridin-2-yl)acetamide

生成物 1

HCID 251966502,2,2-trifluoro-N-(6-fluoro-3-iodoimidazo[1,2-a]pyridin-2-yl)acetamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
0 °C

実験手順

2,2,2-trifluoro-N-(6-fluoroimidazo[1,2-a]pyridin-2-yl)acetamide (0.89 g, 0.0036 mol) was dissolved in acetonitrile (20 mL) and was cooled at 0° C. N-Iodosuccinimide (0.89 g, 0.0040 mol) was added and the reaction was stirred for 30 minutes. The mixture was poured into water (100 mL) and extracted with ethyl acetate (3×100 mL). The combined organics were dried with magnesium sulfate and the solvent removed. The residue was chromatographed on silica (60% ethyl acetate/hexanes) to give 2,2,2-trifluoro-N-(6-fluoro-3-iodoimidazo[1,2-a]pyridin-2-yl)acetamide 4 Rf 0.40, 60% ethyl acetate/hexanes; MS m/z 374 (M+H).

後処理

  1. extractionextracted with ethyl acetate (3×100 mL)
  2. dry with materialThe combined organics were dried with magnesium sulfate
  3. customthe solvent removed
  4. customThe residue was chromatographed on silica (60% ethyl acetate/hexanes)

出典と根拠

ORDレコード
ord-937a188c49ee450f870584f7159dfc03
出典データセット
uspto-grants-2011_11
特許番号
US08058274B2

反応ノート

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