Acetone → HCID 178519775、化合物
反応式
C([O:3][C:4]([C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[CH:8][N:7]=1)=O)C.[BH4-].[Na+].CC(C)=O>C(O)(C)(C)C>[OH:12][C:10]1[N:9]=[CH:8][N:7]=[C:6]([CH2:4][OH:3])[CH:11]=1参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a suspension of 1.7 g (10.1 mMol) 6-hydroxy-pyrimidine-4-carboxylic acid ethyl ester in 30 ml of tert-butanol, 1.2 g (31 mMol) of NaBH4 are added. The mixture is stirred at 60° C. for 20 h and cooled to rt. Then 45 ml of acetone are added. After stirring for 15 min, the mixture is concentrated in vacuo. The residue is diluted with toluene and again concentrated, yielding (6-hydroxy-pyrimidin-4-yl)-methanol (MS: [M−1]=125).
後処理
- additionare added
- temperaturecooled to rt
- stirringAfter stirring for 15 min
- concentrationthe mixture is concentrated in vacuo
- additionThe residue is diluted with toluene
- concentrationagain concentrated
出典と根拠
- ORDレコード
- ord-e2a70db3a1184a15aa0cdf83d5627a1c
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08058276B2
反応ノート
読み込み中…