Hydrazine hydrate (1:1) → HCID 178507390、化合物

HRID 556439ノート

反応式

HRID 556439 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10](Cl)[N:9]=2)=[CH:4][CH:3]=1.O.[NH2:18][NH2:19]>C(O)CC>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[NH:18][N:19]=[C:12]([NH2:13])[C:11]3=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 597666616-(4-Aminophenyl)-2-chloronicotinonitrile

生成物 1

HCID 178507390HCID 178507390、化合物収率 98.4%

試薬・触媒・溶媒 1

HCID 10311-Propanol溶媒

反応条件

温度
130 °C

実験手順

In an appropriately sized microwave reactor, 0.97 mmol (222 mg) of 6-(4-aminophenyl)-2-chloronicotinonitrile is suspended in 3.3 ml of 1-propanol. 0.28 ml (0.290 g, 5.80 mmol, 6 eq.) of hydrazine hydrate is added. The suspension is heated for 45 minutes at 130° C. in a microwave oven. The mixture is filtered and the solid is dried so as to obtain a green solid (215 mg).

後処理

  1. filtrationThe mixture is filtered
  2. customthe solid is dried so as

出典と根拠

ORDレコード
ord-24b5c284da7049d8b6aead65862e563a
出典データセット
uspto-grants-2011_11
特許番号
US08058290B2

反応ノート

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