Ethanolamine → HCID 67339071、化合物
反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH:11]=O)[CH:10]=1)[NH:7][CH:6]=[CH:5]2.[NH2:13][CH2:14][CH2:15][OH:16].[H][H]>CO.[Pd]>[OH:16][CH2:15][CH2:14][NH:13][CH2:11][C:9]1[CH:10]=[C:2]([CH3:1])[CH:3]=[C:4]2[C:8]=1[NH:7][CH:6]=[CH:5]2参加物
6
実験手順
Dissolve 5-Methyl-1H-indole-7-carboxaldehyde (4.036 g, 25.384 mmol) in absolute methanol (200 mL), add 2-aminoethanol (3.1 g, 50.767 mmol) and 10% palladium on carbon (0.4 g). Stir the mixture for 1 hour under nitrogen, then under 1 atmosphere of hydrogen for 3 hours. Filter, concentrate under reduced pressure, and purify by flash column chromatography (silica gel, 90/9/1, dichloromethane/methanol/ammonia) to give the title compound as a colorless oil.
後処理
- filtrationFilter
- concentrationconcentrate under reduced pressure
- custompurify by flash column chromatography (silica gel, 90/9/1, dichloromethane/methanol/ammonia)
出典と根拠
- ORDレコード
- ord-4a6b834cdbfa460b8714536402a26c7e
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08058425B2
反応ノート
読み込み中…