Sodium Hydroxide → 6-fluoro-2,3-dihydro-1H-indole
反応式
C([BH3-])#N.[Na+].[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1.[OH-].[Na+]>C(O)(=O)C>[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH2:10][CH2:11][NH:12]2)=[CH:8][CH:7]=1参加物
5
実験手順
Add sodium cyanoborohydride (5.57 g, 88.78 mmol) to a solution of 6-fluoro-indole (10 g, 73.99 mmol) in acetic acid (100 ml). Stir at room temperature for 30 minutes. Pour the reaction mixture into 5N sodium hydroxide and extract with ethyl acetate. Wash the combined organic phases with saturated aqueous sodium bicarbonate followed by saturated aqueous sodium chloride. Concentrated under reduced pressure and subject the residue to silica gel chromatography to provide the desired compound as a colorless oil (7.69 g, 76%).
後処理
- extractionextract with ethyl acetate
- washWash the combined organic phases with saturated aqueous sodium bicarbonate
- concentrationConcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-5876ebfc213c4646997de813d5d3e5d2
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08058425B2
反応ノート
読み込み中…