Hydrochloric Acid → 4'-(1-(Isopropoxycarbonyl)cyclopropyl)biphenyl-4-carboxylic acid

HRID 557627ノート

反応式

HRID 557627 の反応式
[CH:1]([O:4][C:5]([C:7]1([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([C:22](=[O:24])C)=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].BrBr.[OH-].[Na+].Cl.S(S([O-])=O)([O-])(=O)=[O:31].[Na+].[Na+]>O1CCOCC1.O>[CH:1]([O:4][C:5]([C:7]1([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([OH:31])=[O:24])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:9][CH2:8]1)=[O:6])([CH3:2])[CH3:3]

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24408Bromine2 回HCID 656671Sodium PyrosulfiteHCID 666602881-(4'-Acetylbiphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester

生成物 1

HCID 666604224'-(1-(Isopropoxycarbonyl)cyclopropyl)biphenyl-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 312751,4-Dioxane溶媒

実験手順

To 1-(4′-acetylbiphenyl-4-yl)cyclopropanecarboxylic acid isopropyl ester (11.6 g, 36 mmol) in dioxane (200 mL) at ˜10° C. was added a solution of bromine (28.8 g, 180 mmol), sodium hydroxide (24.5 g, 612 mmol) in water (150 mL). The solution was stirred at room temperature for 30 minutes poured into water (500 mL) and acidified with dilute hydrochloric acid. Sodium metabisulfite was added until the brown bromine color dissipated. The product was filtered and dried in a vacuum over overnight at 40° C. to yield 10 g of the title compound.

後処理

  1. filtrationThe product was filtered
  2. customdried in a vacuum over overnight at 40° C.

出典と根拠

ORDレコード
ord-b5e02b4f28314d53a065d350aa938215
出典データセット
uspto-grants-2011_11
特許番号
US08058300B2

反応ノート

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