1,2-Dichloroethane → Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

HRID 55772

反応式

HRID 55772 の反応式
[F:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[F:12].C(Cl)C[Cl:15].Cl.[N:18]12[CH2:25][CH2:24][CH:21]([CH2:22][CH2:23]1)[CH:20]([CH2:26][C:27](O)=[O:28])[CH2:19]2>C(N(CC)C(C)C)(C)C.ClCCl>[ClH:15].[N:18]12[CH2:23][CH2:22][CH:21]([CH2:24][CH2:25]1)[CH:20]([CH2:26][C:27]([O:8][C:7]1[C:2]([F:1])=[C:3]([F:12])[C:4]([F:11])=[C:5]([F:10])[C:6]=1[F:9])=[O:28])[CH2:19]2

参加物

6

反応物 3

HCID 111,2-DichloroethaneHCID 13041PentafluorophenolHCID 230241472-(Quinuclidin-3-yl)acetic acid hydrochloride

生成物 1

HCID 86610796Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

試薬・触媒・溶媒 2

HCID 81531Diisopropylethylamine触媒HCID 6344Dichloromethane溶媒

実験手順

358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.

後処理

  1. concentrationThe contents of the flask are concentrated in vacuo
  2. customdried under high vacuum
  3. customThe resulting crude product is employed without further purification in the following stages

出典と根拠

ORDレコード
ord-b3b1aaa0e07f4281b55d14c723e1b6a1
出典データセット
uspto-grants-2016_09
特許番号
US09433614B2

関連ノート

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