Pyridine → BROMO-ACETIC ACID 2-FORMYL-PHENYL ESTER

HRID 558031ノート

反応式

HRID 558031 の反応式
[CH:1](=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].N1C=CC=CC=1.[Br:16][CH2:17][C:18](Br)=[O:19]>ClCCl>[CH:1]([C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[O:4][C:18](=[O:19])[CH2:17][Br:16])=[O:9]

参加物

5

反応物 3

HCID 1049PyridineHCID 6998SalicylaldehydeHCID 61147Bromoacetyl bromide

生成物 1

HCID 11470550BROMO-ACETIC ACID 2-FORMYL-PHENYL ESTER収率 60.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of Salicylaldehyde (50 grams) and pyridine (48.5 grams) in dichloromethane (500 ml) maintained at 0-5° C. under nitrogen atmosphere was added dropwise bromoacetyl bromide (210.6 grams). The reaction mixture was stirred for one hour at the same temperature. The reaction mixture was washed with 1000 ml of water and 1500 ml of 5% sodium bicarbonate solution, dried over sodium sulphate followed by distillation of solvent under reduced pressure to get 60.0 grams of bromo-acetic acid 2-formyl-phenyl ester.

後処理

  1. washThe reaction mixture was washed with 1000 ml of water and 1500 ml of 5% sodium bicarbonate solution
  2. dry with materialdried over sodium sulphate
  3. distillationfollowed by distillation of solvent under reduced pressure

出典と根拠

ORDレコード
ord-784a51c58e76457eb6f4b0dd73268bf6
出典データセット
uspto-grants-2011_11
特許番号
US08062653B2

反応ノート

読み込み中…