1,3-Dimethyl-5-nitroisoquinoline → 1,3-Dimethylisoquinolin-5-amine

HRID 559476

反応式

HRID 559476 の反応式
[CH3:1][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-])=O)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([CH3:15])[N:3]=1>[Pd].CO>[NH2:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[CH:5]=[C:4]([CH3:15])[N:3]=[C:2]2[CH3:1]

参加物

4

反応物 1

HCID 574567801,3-Dimethyl-5-nitroisoquinoline

生成物 1

HCID 223376241,3-Dimethylisoquinolin-5-amine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of D3 (2.01 g, 9.94 mM) and 10% palladium on charcoal (1 g) in methanol was hydrogenated at atmospheric pressure for 1 h. The catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the title compound as an off white solid.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8b298f91f862430fb1b4d0d9f7fe359c
出典データセット
uspto-grants-2011_11
特許番号
US08063078B2

関連ノート

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