Water → 7-Benzothiazolecarboxylic acid

HRID 560314ノート

反応式

HRID 560314 の反応式
[OH-].[Na+].C[O:4][C:5]([C:7]1[C:15]2[S:14][CH:13]=[N:12][C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:6].C1COCC1.O>CO>[S:14]1[C:15]2[C:7]([C:5]([OH:6])=[O:4])=[CH:8][CH:9]=[CH:10][C:11]=2[N:12]=[CH:13]1

参加物

6

反応物 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 59316815Methyl benzo[d]thiazole-7-carboxylate

生成物 1

HCID 450769847-Benzothiazolecarboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

At 0° C. an aq. NaOH solution (50%, 6.0 mL) is added to a solution of benzothiazole-7-carboxylic acid methyl ester in a mixture of MeOH (39 mL), THF (11.7 mL) and water (3.0 mL). The mixture is stirred for 4 h and concentrated in vacuo. At 0° C. water (60 mL) is added and the mixture is made acidic (pH 5) by addition of conc. HCl. After 30 min the precipitate is filtered off, washed with water and dried in vacuo to give the desired product.

後処理

  1. concentrationconcentrated in vacuo
  2. additionAt 0° C. water (60 mL) is added
  3. additionby addition of conc. HCl
  4. filtrationAfter 30 min the precipitate is filtered off
  5. washwashed with water
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-6fd7288e3c5d487dbfa3fa6a044b37cd
出典データセット
uspto-grants-2011_11
特許番号
US08063099B2

反応ノート

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