Ethyl Bromide → 2-(4-Ethoxyphenyl)thiazole

HRID 56085

反応式

HRID 56085 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:20][CH3:21]>CC(C)=O>[CH2:20]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)=[CH:6][CH:7]=1)[CH3:21]

参加物

5

反応物 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 2238404-(1,3-Thiazol-2-yl)phenol

生成物 1

HCID 691606082-(4-Ethoxyphenyl)thiazole収率 100%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a mixture of 2-(4-hydroxyphenyl)thiazole (21.27 g, 0.12 mol) and K2CO3 (82.93 g, 0.60 mol) in acetone (1000 mL) was added bromoethane (39.24 g, 0.36 mol) with stirring at rt. The reaction mixture was heated at 60° C. for 11 h, then cooled to rt, filtered and concentrated in vacuo to give the title compound as a white solid (24.54 g, 100%).

後処理

  1. temperatureThe reaction mixture was heated at 60° C. for 11 h
  2. temperaturecooled to rt
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1ffa6d2b914f46358351db5fa944536d
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

読み込み中…