4-(2-Fluoro-4-nitrophenyl)-1lambda~6~,4-thiazinane-1,1-dione → 4-(4-Amino-2-fluorophenyl)thiomorpholine 1,1-dioxide

HRID 56098ノート

反応式

HRID 56098 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][S:14](=[O:18])(=[O:17])[CH2:13][CH2:12]1>C1COCC1.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:16][CH2:15][S:14](=[O:17])(=[O:18])[CH2:13][CH2:12]2)=[C:2]([F:1])[CH:7]=1

参加物

4

反応物 1

HCID 159843694-(2-Fluoro-4-nitrophenyl)-1lambda~6~,4-thiazinane-1,1-dione

生成物 1

HCID 435813994-(4-Amino-2-fluorophenyl)thiomorpholine 1,1-dioxide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-(2-fluoro-4-nitrophenyl)1,1-dioxidothiomorpholine (4.00 g, 14.58 mmol) in THF (50 mL) was added Pd/C (1.30 g). The reaction mixture was stirred at rt under H2 for 12 h. The mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound as an offwhite solid (2.40 g, 67%).

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-4b4a2f8296c64eaa909b715e8b62270f
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

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