反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:15]=[CH:14][C:10]([C:11](=[S:13])[NH2:12])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:17][CH:18](OC)OC.C1(C)C=CC(S(O)(=O)=O)=CC=1>CCO>[S:13]1[CH:18]=[CH:17][N:12]=[C:11]1[C:10]1[CH:9]=[CH:8][C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)=[CH:15][CH:14]=1参加物
5
反応条件
- 温度
- 95 °C
実験手順
To a solution of 4-morpholinobenzothioamide (2.22 g, 10 mmol) in EtOH (50 mL) were added 2-bromo-1,1-dimethoxyethane (1.69 g, 10 mmol) and p-toluenesulfonic acid (1.90 g, 10 mmol). The reaction mixture was heated at 95° C. overnight, then cooled to rt and filtered. The filter cake was dried to give the title compound as a yellow solid (2.00 g, 81%).
後処理
- temperaturecooled to rt
- filtrationfiltered
- customThe filter cake was dried
出典と根拠
- ORDレコード
- ord-f1d7e3e5dde646d382393bff6ab00702
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434695B2
関連ノート
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