4-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanol → 1-(Benzo[d][1,3]dioxol-5-yl)-1-cyclopropylethanol

HRID 561467

反応式

HRID 561467 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]2[O:10][CH2:11][O:12][C:6]=2[CH:5]=1)=[O:3].[CH:13]1([Mg]Br)[CH2:15][CH2:14]1.C1(C(C2C=CC(Cl)=CC=2)(O)C)CC1>O1CCCC1>[O:10]1[C:7]2[CH:8]=[CH:9][C:4]([C:2]([CH:13]3[CH2:15][CH2:14]3)([OH:3])[CH3:1])=[CH:5][C:6]=2[O:12][CH2:11]1

参加物

5

反応物 3

HCID 234634-Chloro-alpha-cyclopropyl-alpha-methylbenzenemethanolHCID 76622AcetopiperoneHCID 178418630HCID 178418630、化合物

生成物 1

HCID 583922611-(Benzo[d][1,3]dioxol-5-yl)-1-cyclopropylethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound was prepared starting from 1.50 g (9.14 mmol) of 3,4-(methylenedioxy)acetophenone and 36.5 ml (18.28 mmol) of a 0.5N solution of cyclopropylmagnesium bromide in tetrahydrofuran in analogy to the synthesis of the compound from Example 138A. 1.32 g (70% of theory) of the title compound were obtained.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-83377f42d1354a9da6ac332978b01b77
出典データセット
uspto-grants-2011_11
特許番号
US08063234B2

関連ノート

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