HCID 28972568、化合物 → 2-fluoro-N1-(2-morpholinoethyl)benzene-1,4-diamine

HRID 56158ノート

反応式

HRID 56158 の反応式
[F:1][C:2]1[CH:16]=[C:15]([N+:17]([O-])=O)[CH:14]=[CH:13][C:3]=1[NH:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>C1COCC1.[Pd]>[F:1][C:2]1[CH:16]=[C:15]([NH2:17])[CH:14]=[CH:13][C:3]=1[NH:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1

参加物

4

反応物 1

HCID 28972568HCID 28972568、化合物

生成物 1

HCID 176096902-fluoro-N1-(2-morpholinoethyl)benzene-1,4-diamine収率 94%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-fluoro-N-(2-morpholinoethyl)-4-nitroaniline (0.60 g, 2.23 mmol) in THF (8.0 mL) was added catalyst Pd/C (0.03 g). The reaction mixture was stirred at rt under H2 overnight, then filtered. The filtrate was concentrated in vacuo to give the title compound as yellow oil (0.50 g, 94%).

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-ceb74fd6c07a4d9aa90d96551da23d0d
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

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