Azobisisobutyronitrile → 2-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

HRID 561794ノート

反応式

HRID 561794 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[CH:4][C:3]=1[CH3:13].[Br:14]N1C(=O)CCC1=O.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[Br:14][CH2:13][C:3]1[CH:4]=[C:5]([O:8][CH2:9][CH2:10][O:11][CH3:12])[CH:6]=[CH:7][C:2]=1[Cl:1]

参加物

5

反応物 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 22467254HCID 22467254、化合物

生成物 1

HCID 591775552-(Bromomethyl)-1-chloro-4-(2-methoxyethoxy)benzene

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 1-chloro-4-(2-methoxyethoxy)-2-methylbenzene from the previous step (1 eq.) in carbon tetrachloride (0.02 M) was added N-bromosuccinimide (1 eq.) and a few crystals of AIBN (1.1 eq.). The resulting mixture was irradiated with sunlamp at reflux for 1 h. The insolubles were removed via filtration and the filtrate was concentrated in vacuo to furnish the title compound.

後処理

  1. customThe resulting mixture was irradiated with sunlamp
  2. temperatureat reflux for 1 h
  3. customThe insolubles were removed via filtration
  4. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-5e9a531dabde4f8f95c5003ed456e315
出典データセット
uspto-grants-2011_11
特許番号
US08063105B2

反応ノート

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