Imidazole → ethyl 2-(1H-imidazol-1-yl)acetate

HRID 562445ノート

反応式

HRID 562445 の反応式
[Na].[NH:2]1[CH:6]=[CH:5][N:4]=[CH:3]1.Br[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(O)C>[N:2]1([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=[CH:3]1

参加物

5

反応物 3

HCID 795ImidazoleHCID 7748Ethyl bromoacetateHCID 5360545Sodium

生成物 1

HCID 3798501ethyl 2-(1H-imidazol-1-yl)acetate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

118.2 g (5.1 mmol) of sodium are added slowly to 2.5 litres of ethanol. 350.0 g (5.1 mol) of imidazole and 570 ml (858.6 g, 5.1 mol) of ethyl bromoacetate are added dropwise at an internal temperature of 20-25° C. The mixture is stirred at RT for 24 h. The precipitated solid is filtered off, the ethanol is removed under reduced pressure and the mixture is filtered again. The residue is purified by column chromatography on silica gel (mobile phase ethyl acetate). Yield: 639.0 g (81% of theory)

後処理

  1. filtrationThe precipitated solid is filtered off
  2. customthe ethanol is removed under reduced pressure
  3. filtrationthe mixture is filtered again
  4. customThe residue is purified by column chromatography on silica gel (mobile phase ethyl acetate)

出典と根拠

ORDレコード
ord-2c36d1f0258c4a30833050141901c87b
出典データセット
uspto-grants-2011_11
特許番号
US08067407B2

反応ノート

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