Hydrochloric Acid → 4-(1,3-Dioxo-1,3-dihydro-isoindol-2-YL)-benzenesulfonamide

HRID 562666

反応式

HRID 562666 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:12](Cl)(=[O:22])[C:13]1[C:14](=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:15](Cl)=[O:16].Cl>N1C=CC=CC=1>[O:16]=[C:15]1[C:14]2[CH:18]=[CH:19][CH:20]=[CH:21][C:13]=2[C:12](=[O:22])[N:1]1[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:9])=[O:10])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 5333SulfanilamideHCID 6955Phthaloyl chloride

生成物 1

HCID 35864944-(1,3-Dioxo-1,3-dihydro-isoindol-2-YL)-benzenesulfonamide収率 90.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
60 °C

実験手順

A solution of 1.0 g (5.8 mmol) of p-aminophenylsulfonamide in 3.6 ml, of pyridine was added 878 μL (6.1 mmol) of phthalic dichloride. After heating to 60° C. for 18 h, the solution was poured into 1N HCl, cooled to 0° C., the precipitate was collected by filtration, and dried under vacuum to give 1.58 g (90%) of the titled compound.

後処理

  1. temperaturecooled to 0° C.
  2. filtrationthe precipitate was collected by filtration
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-539260aa2312491baa5caf7704b5ad4a
出典データセット
uspto-grants-2011_11
特許番号
US08067428B2

関連ノート

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