3-Hydroxypyridine → 2-(Pyridin-3-yloxy)acetonitrile

HRID 56268ノート

反応式

HRID 56268 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([OH:7])[CH:2]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:15][C:16]#[N:17]>CC#N>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH2:15][C:16]#[N:17])[CH:2]=1

参加物

5

反応物 3

HCID 79713-HydroxypyridineHCID 11430Potassium CarbonateHCID 11534Bromoacetonitrile

生成物 1

HCID 199146182-(Pyridin-3-yloxy)acetonitrile収率 16%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a mixture of pyridin-3-ol (4.0 g, 42.1 mmol) and K2CO3 (6.96 g, 50.4 mmol) in CH3CN (6 mL) was added dropwise 2-bromoacetonitrile (2.52 g, 21.0 mmol) at rt and the mixture was stirred at rt for 40 h. The mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=2:1) to give the title compound as a yellow solid (0.45 g, 16%).

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=2:1)

出典と根拠

ORDレコード
ord-bf1779f436194aab9f739c5a14f10a16
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

読み込み中…