Tetrahydrofuran → 3,5-Difluoro-4-(morpholin-4-yl)aniline

HRID 56298ノート

反応式

HRID 56298 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.C1COCC1>[Pd].C(O)C>[F:11][C:4]1[CH:5]=[C:6]([CH:7]=[C:2]([F:1])[C:3]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[NH2:8]

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 223856304-(2,6-Difluoro-4-nitrophenyl)morpholine

生成物 1

HCID 218781683,5-Difluoro-4-(morpholin-4-yl)aniline収率 88%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 4-(2,6-difluoro-4-nitrophenyl)morpholine (4.71 g, 19.3 mmol), THF (30 mL), ethanol (30 mL) and Pd/C (2.0 g, 10%) was stirred at rt under H2 overnight. The mixture was filtered and concentrated in vacuo and the residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=8:1) to give the title compound as a yellow solid (3.62 g, 88%).

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo
  3. customthe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=8:1)

出典と根拠

ORDレコード
ord-426bb2edf27046da964079bf5092389d
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

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