Benzyl Alcohol → (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid

HRID 563549ノート

反応式

HRID 563549 の反応式
F[C:2]1[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:16]([OH:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[H-].[Na+]>CN1C(=O)CCC1>[CH2:16]([O:23][C:2]1[CH:3]=[C:4]([CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 27591723-Fluoro-5-(trifluoromethyl)phenylacetic acid

生成物 1

HCID 59644613(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
120 °C

実験手順

To 3-fluoro-5-(trifluoromethyl)phenylacetic acid (2.0 g, 9.0 mmol) and benzyl alcohol (1.9 mL, 18.0 mmol) in NMP (10 mL) was added sodium hydride (60% in mineral oil; 0.8 g, 19.8 mmol), and the reaction was stirred at 120° C. for 3 hours. The mixture was acidified and extracted with EtOAc, and the crude material was purified by silica gel chromatography to give the title compound.

後処理

  1. extractionextracted with EtOAc
  2. customthe crude material was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-429b6ce40a85418c86226b0a2f758d7a
出典データセット
uspto-grants-2011_11
特許番号
US08067445B2

反応ノート

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