5-Bromo-2-fluorobenzaldehyde → (5-Bromo-2-fluorophenyl)methanol

HRID 563785

反応式

HRID 563785 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH2:7][OH:8])[CH:9]=1

参加物

4

反応物 2

HCID 7363275-Bromo-2-fluorobenzaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 2773352(5-Bromo-2-fluorophenyl)methanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 5-bromo-2-fluorobenzaldehyde (1.3 g, 6.4 mmol) in MeOH (10 mL) was added sodium borohydride (0.29 g, 7.7 mmol), and the reaction was stirred at room temperature for 5 minutes. After aqueous work-up, the residue was purified by silica gel chromatography to give the title compound.

後処理

  1. customAfter aqueous work-up, the residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-e013470df19541eaa101c5ba8cb8d399
出典データセット
uspto-grants-2011_11
特許番号
US08067445B2

関連ノート

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