5-Bromo-2-fluorobenzaldehyde → (5-Bromo-2-fluorophenyl)methanol
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH2:7][OH:8])[CH:9]=1参加物
4
実験手順
To a solution of 5-bromo-2-fluorobenzaldehyde (1.3 g, 6.4 mmol) in MeOH (10 mL) was added sodium borohydride (0.29 g, 7.7 mmol), and the reaction was stirred at room temperature for 5 minutes. After aqueous work-up, the residue was purified by silica gel chromatography to give the title compound.
後処理
- customAfter aqueous work-up, the residue was purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-e013470df19541eaa101c5ba8cb8d399
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08067445B2
反応ノート
読み込み中…