2-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide → HCID 67008363、化合物

HRID 563999ノート

反応式

HRID 563999 の反応式
[Cl:1][C:2]1[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[C:9]2[CH:15]=[CH:14][NH:13][C:10]2=[N:11][CH:12]=1)=[O:5]>C1COCC1.[Pt]>[NH2:20][C:17]1[CH:18]=[CH:19][C:2]([Cl:1])=[C:3]([CH:16]=1)[C:4]([NH:6][C:7]1[CH:8]=[C:9]2[CH:15]=[CH:14][NH:13][C:10]2=[N:11][CH:12]=1)=[O:5]

参加物

4

反応物 1

HCID 670082132-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

生成物 1

HCID 67008363HCID 67008363、化合物

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8028Tetrahydrofuran溶媒

実験手順

3.85 g 2-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide in 600 ml THF were hydrogenated over 2.5 g platinum on carbon at atmospheric pressure over night at RT. The catalyst was removed by filtration and the filtrate evaporated. The residue was purified by chromatography on silica eluting first with ethyl acetate and finally ethyl acetate/methanol mixtures.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. customThe residue was purified by chromatography on silica eluting first with ethyl acetate and finally ethyl acetate/methanol mixtures

出典と根拠

ORDレコード
ord-d84155c130044411b5548d9df9afe9f9
出典データセット
uspto-grants-2011_11
特許番号
US08067599B2

反応ノート

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