2-Amino-3,5-dinitropyridine → Pyridine-2,3,5-triamine

HRID 564001ノート

反応式

HRID 564001 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([N+:11]([O-])=O)=[CH:4][N:3]=1>CO.C1COCC1.[Pd]>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([NH2:11])=[CH:4][N:3]=1

参加物

5

反応物 1

HCID 5043402-Amino-3,5-dinitropyridine

生成物 1

HCID 14626209Pyridine-2,3,5-triamine収率 98.2%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

5 g 2-Amino-3,5-dinitropyridine in a mixture of 66 ml methanol and 33 ml THF were hydrogenated over 800 mg 10% palladium on charcoal at room temperature and atmospheric pressure. After the calculated amount of hydrogen was consumed, the catalyst was filtered off and the filtrate was concentrated under vacuum yielding 3.31 g of the crude product which was used for the next step without further purification.

後処理

  1. customAfter the calculated amount of hydrogen was consumed
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under vacuum

出典と根拠

ORDレコード
ord-6e29d33d1009406391acf6a39d00ad7a
出典データセット
uspto-grants-2011_11
特許番号
US08067599B2

反応ノート

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