Dimethylformamide → 2-(3-Bromophenyl)-2-methylpropanenitrile

HRID 564015ノート

反応式

HRID 564015 の反応式
[H-].[Na+].[Br:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11]#N)[CH:7]=[CH:8][CH:9]=1.I[CH3:14].C[N:16]([CH:18]=O)C>C(OCC)C>[Br:3][C:4]1[CH:5]=[C:6]([C:10]([CH3:11])([CH3:14])[C:18]#[N:16])[CH:7]=[CH:8][CH:9]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 36023(3-Bromophenyl)acetonitrile

生成物 1

HCID 105132942-(3-Bromophenyl)-2-methylpropanenitrile

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

257 mg 95% sodium hydride were stirred at room temperature in 25 ml dry DMF under an atmosphere of nitrogen. A solution of 1 g 3-bromophenylacetonitrile and 1.593 g iodomethane in 10 ml dry diethyl ether was added slowly below 30° C. The mixture was stirred over night at room temperature and then quenched by addition of a small amount of water. The solvents were evaporated under vacuum and the residue was purified by chromatography on silica in a heptane/ethyl acetate gradient.

後処理

  1. customquenched by addition of a small amount of water
  2. customThe solvents were evaporated under vacuum
  3. customthe residue was purified by chromatography on silica in a heptane/ethyl acetate gradient

出典と根拠

ORDレコード
ord-06100fb05b61410ea109aedc47e1e36e
出典データセット
uspto-grants-2011_11
特許番号
US08067599B2

反応ノート

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