Water → 2-Acetyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide

HRID 564735ノート

反応式

HRID 564735 の反応式
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:12]2[CH:21]=[C:20]([C:22](OC)([O:24]C)[CH3:23])[O:19][C:13]=2[C:14]([O:17][CH3:18])=[N:15][CH:16]=1)=[O:10].FC(F)(F)C(O)=O.O>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:12]2[CH:21]=[C:20]([C:22](=[O:24])[CH3:23])[O:19][C:13]=2[C:14]([O:17][CH3:18])=[N:15][CH:16]=1)=[O:10]

参加物

6

反応物 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 700816022-(1,1-Dimethoxyethyl)-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide

生成物 1

HCID 867561882-Acetyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide収率 83.7%

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 6344Dichloromethane溶媒

実験手順

2-(1,1-Dimethoxyethyl)-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide (0.15 g), trifluoroacetic acid (0.23 ml) and water (0.50 ml) were stirred at 50° C. in chloroform (20 ml) for 4 h. The mixture was cooled and diluted with dichloromethane (30 ml), washed with saturated sodium bicarbonate solution (30 ml) then water (30 ml), dried over magnesium sulfate, filtered and the solvent removed in vacuo to give the title compound (0.11 g) as a cream solid.

後処理

  1. temperatureThe mixture was cooled
  2. washwashed with saturated sodium bicarbonate solution (30 ml)
  3. dry with materialwater (30 ml), dried over magnesium sulfate
  4. filtrationfiltered
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-0b1df72aa6ac4ecca8134a7d8c70ac35
出典データセット
uspto-grants-2001_01
特許番号
US06169090A

反応ノート

読み込み中…