O-Phenylenediamine → 1H-Benzimidazole-2-acetonitrile

HRID 565076

反応式

HRID 565076 の反応式
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].[C:9]([CH2:11][C:12](OCC)=O)#[N:10]>C(OCCC)(=O)C>[N:7]1[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[NH:8][C:12]=1[CH2:11][C:9]#[N:10]

参加物

4

反応物 2

HCID 7243O-PhenylenediamineHCID 7764Ethyl cyanoacetate

生成物 1

HCID 204551H-Benzimidazole-2-acetonitrile

試薬・触媒・溶媒 1

HCID 7997Propyl Acetate溶媒

実験手順

Benzimidazole-2-acetonitrile was prepared as follows. A mixture of o-phenylenediamine (1 mole) and ethyl cyanoacetate (2 moles) was refluxed for about 30 hours, cooled, diluted with propyl acetate (225 mL), filtered, washed and dried, to provide benzimidazole-2-acetonitrile in a 60-70% yield. Benzimidazole-2-acetonitrile is also available commercially from Aldrich Chemical Company.

後処理

  1. customBenzimidazole-2-acetonitrile was prepared
  2. temperaturewas refluxed for about 30 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. washwashed
  6. customdried

出典と根拠

ORDレコード
ord-a970094587af454482a0d3fad6c612f0
出典データセット
uspto-grants-2001_01
特許番号
US06169185A

関連ノート

読み込み中…