Hydrochloric Acid → HCID 21266158、化合物

HRID 566424

反応式

HRID 566424 の反応式
[CH2:1]([NH2:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[C@@H:16]12[C:25](=O)[O:24][C:22](=[O:23])[C@@H:17]1[CH2:18][CH:19]=[CH:20][CH2:21]2.[BH4-].[Na+].Cl>O.CC(O)C>[OH:24][CH2:25][CH:16]1[CH:17]([C:22]([NH:15][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[O:23])[CH2:18][CH:19]=[CH:20][CH2:21]1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 16217TetradecylamineHCID 98495Tetrahydrophthalic anhydride, cis-HCID 4311764Sodium borohydride

生成物 1

HCID 21266158HCID 21266158、化合物収率 93.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3776Isopropanol溶媒

反応条件

温度
140 °C

実験手順

1-Tetradecylamine (3.51 g) was added to cis-4-cyclohexene-1,2-dicarboxylic anhydride (2.50 g) and stirred for 5 hours at 140° C. The reaction mixture was suspended into a mixed solution of 2-propanol (125 ml) and water (21 ml) and then sodium borohydride (3.11 g) was added thereto at room temperature. After being stirred for 67.5 hours at room temperature, the reaction mixture was acidified with dilute hydrochloric acid. The resulting solid was collected by filtration under a vacuum, washed with water, and dried, thereby yielding the entitled compound (5.38 g) as white solid.

後処理

  1. customat room temperature
  2. stirringAfter being stirred for 67.5 hours at room temperature
  3. filtrationThe resulting solid was collected by filtration under a vacuum
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-478abe3bf9a9404bbfcca86e0ea2e081
出典データセット
uspto-grants-2001_01
特許番号
US06174885B1

関連ノート

読み込み中…