Sodium hydride → Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-methylbutanoate

HRID 56654

反応式

HRID 56654 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.Br[CH:10]([CH:16]([CH3:18])[CH3:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12].[H-].[Na+].[Br-].[Li+]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:10]([CH:16]([CH3:18])[CH3:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:4](=[O:8])[CH:3]=1

参加物

5

反応物 4

HCID 24758Sodium hydrideHCID 79068Ethyl 2-bromoisovalerateHCID 82050Lithium BromideHCID 8171154-Bromo-2-hydroxypyridine

生成物 1

HCID 117622680Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-methylbutanoate

実験手順

500 mg (2.9 mmol) of 4-bromopyridin-2(1H)-one and 841 mg (4.02 mmol) of ethyl 2-bromo-3-methylbutanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C. Yield: 260 mg (purity 92%, 28% of theory)

出典と根拠

ORDレコード
ord-c500bff0312245cb8bcb8b8c72a9fb80
出典データセット
uspto-grants-2016_09
特許番号
US09434690B2

関連ノート

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