Sodium Hydroxide → HCID 287914、化合物
反応式
[C:1]1([CH:11]=[CH:12]C(=O)C)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.Cl.[NH2:17][OH:18].[OH-].[Na+]>CO>[C:5]1([CH:4]=[CH:3][CH:2]=[CH:1][C:11](=[N:17][OH:18])[CH3:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
5
実験手順
In a 250 ml single neck flask was charged 5.28 g (30 mmoles, 1.0 eq.) of 4-(1-naphthyl)-3-buten-2-one and 5.2 g (75.4 mmoles, 2.5 eq) of hydroxylamine hydrochloride and 6 g of 50% sodium hydroxide (75 mmoles, 2.5 eq) and 100 ml of methanol. The reaction mixture was stirred at reflux for 2 hours. The reaction mixture was concentrated, diluted with water (50 ml), and then extracted with ethyl acetate (2×50 ml). The organic phase was dried and concentrated, to obtain 3.4 of 4-(2-phenylethenyl)-3-buten-2one 2-oxime (E/Z mixture of isomers) as an oil in 60.6% yield.
後処理
- temperatureat reflux for 2 hours
- concentrationThe reaction mixture was concentrated
- additiondiluted with water (50 ml)
- extractionextracted with ethyl acetate (2×50 ml)
- customThe organic phase was dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-bbc76902b28942809b3a03a6dfa78123
- 出典データセット
- uspto-grants-2001_01
- 特許番号
- US06177462B1
反応ノート
読み込み中…