1-Propanol → Sampatrilat

HRID 567942ノート

反応式

HRID 567942 の反応式
O.[C:2]([C@H:5]([CH2:27][NH:28][C:29](=[O:41])[C@H:30]([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH2:6][C:7]1([C:12]([NH:14][C@H:15]([C:24]([OH:26])=[O:25])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1)([OH:4])=[O:3].C(O)CC>C(#N)C>[C:2]([C@H:5]([CH2:27][NH:28][C:29](=[O:41])[C@H:30]([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH2:6][C:7]1([C:12]([NH:14][C@H:15]([C:24]([OH:26])=[O:25])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1)([OH:4])=[O:3]

参加物

4

反応物 2

HCID 10311-PropanolHCID 86756334HCID 86756334、化合物

生成物 1

HCID 6324648Sampatrilat

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

(S,S,S)-N-(1-[2-Carboxy-3-(N2-mesyllysylamino)propyl]-1-cyclopentylcarbonyl)tyrosine hydrate (the δ-form, see Preparation 2) (1.0 g) was stirred with either n-propanol or acetonitrile (10 ml) for 24 hours at room temperature. In each case the white solid obtained was collected by filtration and dried to provide the title compound, m.p. 172-176° C.

後処理

  1. customPreparation 2) (1.0 g)
  2. customIn each case the white solid obtained
  3. filtrationwas collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-6b682b1f5ed94bd4b8562c1aa519786b
出典データセット
uspto-grants-2001_01
特許番号
US06180665B2

反応ノート

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