m-Chloroperbenzoic acid → HCID 20150758、化合物

反応式

[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][CH2:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[S:7][C:6]=2[CH:16]=1.ClC1C=CC=C(C(OO)=O)C=1.[OH-:28].[Ca+2].[OH-:30]>C(Cl)Cl>[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[S:7](=[O:30])(=[O:28])[C:6]=2[CH:16]=1

参加物

反応条件

温度: 0 °C

実験手順

A mixture of 10.11-dihydro-7-hydroxydibenzo [b,f][1,4]thiazepin (2.2 g,10 mmoles) and m-chloroperbenzoic acid (3.4 g,20 mmoles) in methylene chloride (250 ml) was stirred at 0° C. for 1 hour. The reaction mixture was treated with 4 g of calcium hydroxide for 15 minutes and was then filtered. The filtrate was chromatographed on silica gel, eluting with 5% methanol in chloroform, to yield the title compound, m.p. 202° (dec.).