Water → alpha-(2,3-Dichloro-4-methoxyphenyl)-2-pyridinemethanol

HRID 568641

反応式

HRID 568641 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C([Li])CCC.[Cl:13][C:14]1[C:21]([Cl:22])=[C:20]([O:23][CH3:24])[CH:19]=[CH:18][C:15]=1[CH:16]=[O:17].O>C1COCC1>[Cl:13][C:14]1[C:21]([Cl:22])=[C:20]([O:23][CH3:24])[CH:19]=[CH:18][C:15]=1[CH:16]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1)[OH:17]

参加物

6

反応物 4

HCID 962WaterHCID 79732-BromopyridineHCID 130156892,3-Dichloro-4-methoxybenzaldehydeHCID 178418339Butyllithium

生成物 1

HCID 13015690alpha-(2,3-Dichloro-4-methoxyphenyl)-2-pyridinemethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
-65 °C

実験手順

29.3 g of 2-bromopyridine in 150 ml of dry THF is added to 75 ml of 2.6M n-butyllithium that was chilled to -65° C. 2,3-dichloro-4-methoxybenzaldehyde (38.0 g) is then added in 300 ml of THF and the reaction mixture allowed to come to room temperature. It is poured into H2O and the crystalline product filtered off, washed with ether and dried to give α-(2,3-dichloro-4-methoxyphenyl)-2-pyridinemethanol, mp 174°-176° C.

後処理

  1. customto come to room temperature
  2. filtrationthe crystalline product filtered off
  3. washwashed with ether
  4. customdried

出典と根拠

ORDレコード
ord-386848d5c489420ea7ebd52b0c9b35f7
出典データセット
uspto-grants-1988_03
特許番号
US04728662

関連ノート

読み込み中…