Methyl iodide → 6-Methoxythieno[3,2-b]pyridine

HRID 569072ノート

反応式

HRID 569072 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[H-].[Na+].[CH3:13]I>CS(C)=O>[CH3:13][O:1][C:2]1[CH:3]=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 20148567Thieno[3,2-b]pyridin-6-ol

生成物 1

HCID 201485826-Methoxythieno[3,2-b]pyridine収率 78.5%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

To a solution of 6-hydroxythieno[3,2-b]pyridine (2.45 g, 16.2 mmol) in dry dimethylsulfoxide (15 ml), under a nitrogen atmosphere, was added 60% sodium hydride in mineral oil (0.75 g, 19 mmol) and let stir at room temperature for 1 hour. Methyl iodide (1.25 ml, 21 mmol) was added to this solution and it was stirred for an additional two hours. The solution was poured into ice/water and extracted with diethyl ether, washed with water, dried over anhydrous sodium sulfate, filtered and carefully evaporated to give an oily product (2.1 g, 78% yield) which was used as is.

後処理

  1. stirringwas stirred for an additional two hours
  2. extractionextracted with diethyl ether
  3. washwashed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. customcarefully evaporated

出典と根拠

ORDレコード
ord-5e4ad5e54b854f339997a2ef5d46f549
出典データセット
uspto-grants-1988_03
特許番号
US04731368

反応ノート

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