Trifluoroacetic acid → 7-Amino-3vinyl-3-cephem-4-carboxylic acid

HRID 569373

反応式

HRID 569373 の反応式
C(=[N:9][CH:10]1[C:35](=[O:36])[N:12]2[C:13]([C:19]([O:21]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:20])=[C:14]([CH:17]=[CH2:18])[CH2:15][S:16][C@H:11]12)C1C(=CC=CC=1)O.FC(F)(F)C(O)=O.C(OC(C)C)(C)C>C(Cl)Cl.C1(OC)C=CC=CC=1>[NH2:9][CH:10]1[C:35](=[O:36])[N:12]2[C:13]([C:19]([OH:21])=[O:20])=[C:14]([CH:17]=[CH2:18])[CH2:15][S:16][C@H:11]12

参加物

6

反応物 3

HCID 6422Trifluoroacetic acidHCID 7914Diisopropyl EtherHCID 136460592HCID 136460592、化合物

生成物 1

HCID 128180067-Amino-3vinyl-3-cephem-4-carboxylic acid収率 54.9%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 7519Anisole溶媒

実験手順

To a solution of benzhydryl 7-salicylideneamino-3-vinyl-3-cephem-4-carboxylate (1.6 g) in methylene chloride (20 ml) and anisole (5 ml) was added dropwise trifluoroacetic acid (6 ml) with stirring, and the stirring was continued at ambient temperature for an hour. The reaction mixture was poured into diisopropyl ether, and the precipitates were collected by filtration and then suspended in water, followed by adjusting to pH 3.5 with a saturated aqueous sodium bicarbonate. The solid was collected by filtration to give 7-amino-3-vinyl-3-cephem-4-carboxylic acid (0.4 g).

後処理

  1. waitthe stirring was continued at ambient temperature for an hour
  2. filtrationthe precipitates were collected by filtration
  3. filtrationThe solid was collected by filtration

出典と根拠

ORDレコード
ord-5d38b4a9ac3848388ab573dcc173fb25
出典データセット
uspto-grants-1988_03
特許番号
US04731443

関連ノート

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