Diisobutylaluminum hydride → (1H-indol-5-yl)methanol

HRID 569739

反応式

HRID 569739 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10](OC)=[O:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.CC(C[AlH]CC(C)C)C>CCOCC>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][OH:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

参加物

4

反応物 2

HCID 14487Diisobutylaluminum hydrideHCID 2737635methyl 1H-indole-5-carboxylate

生成物 1

HCID 2773458(1H-indol-5-yl)methanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

96 g (0.548 mole) of 6b are treated analogously to Example 1a in 1,800 ml of ether and 1,391 ml (1.67 moles) of DIBAL (1.2 molar in toluene). After chromatography on silica gel with gradient elution with petroleum ether/ethyl acetate (3:1) and petroleum ether/ethyl acetate (1:1), 39.3 g (49%) of pure product are obtained. C9H9NO (147.2)

後処理

  1. washAfter chromatography on silica gel with gradient elution with petroleum ether/ethyl acetate (3:1) and petroleum ether/ethyl acetate (1:1), 39.3 g (49%) of pure product
  2. customare obtained

出典と根拠

ORDレコード
ord-bc1b83dde3684cc4aa27d378a6abf204
出典データセット
uspto-grants-1988_03
特許番号
US04734407

関連ノート

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