Sodium Hydroxide → 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide

HRID 569811

反応式

HRID 569811 の反応式
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][C:11]=2[F:17])=[O:7])=[C:4]([N+:20]([O-])=O)[CH:3]=1.[OH-].[Na+]>C(O)(=O)C.[Fe]>[NH2:20][C:4]1[CH:3]=[C:2]([Br:1])[CH:19]=[CH:18][C:5]=1[C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][C:11]=1[F:17])=[O:7]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 144589874-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide

生成物 1

HCID 144589952-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide収率 98%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide (3.4 g) and iron (1.45 g) in acetic acid (66 ml) was stirred at 100° C. for 30 minutes. After cooling, iron was filtered off. The filtrate was evaporated to give a residue, which was made alkaline with aqueous 1N sodium hydroxide and extracted with ethyl acetate. The extract was washed with water and dried. Removal of the solvent gave 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide (3.10 g).

後処理

  1. temperatureAfter cooling
  2. filtrationiron was filtered off
  3. customThe filtrate was evaporated
  4. customto give a residue, which
  5. extractionextracted with ethyl acetate
  6. washThe extract was washed with water
  7. customdried
  8. customRemoval of the solvent

出典と根拠

ORDレコード
ord-6cdceda0523d43728be68130110121d7
出典データセット
uspto-grants-1988_03
特許番号
US04734419

関連ノート

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