Methyl 2-furoate → Methyl tetrahydrofuran-2-carboxylate

HRID 569925

反応式

HRID 569925 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8][CH3:9])=[O:7]>CO.[Pd]>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([O:8][CH3:9])=[O:7]

参加物

4

反応物 1

HCID 11902Methyl 2-furoate2 回

生成物 1

HCID 169922Methyl tetrahydrofuran-2-carboxylate収率 92%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Methyl furoate (75 g, 0.595 mole) was dissolved in MeOH (150 ml), and poured into a Parr bottle. Air was replaced with argon, and then 10% Pd/C (2.5 g) was added. The atmosphere was replaced with H2 and methyl furoate was hydrogenated at 40 psi for 48 hours. The reaction was filtered through celite pad, and the pad was washed with ether. The filtrate and the wash were combined and distilled to give the title compound (71 g, 0.546 mole, 59° C./5.1 mmHg, 92%) as a colorless liquid.

後処理

  1. additionpoured into a Parr bottle
  2. filtrationThe reaction was filtered through celite pad
  3. washthe pad was washed with ether
  4. distillationdistilled

出典と根拠

ORDレコード
ord-b6bad2c91bf244d1a8fcdf4e4b97bc17
出典データセット
uspto-grants-1988_03
特許番号
US04734424

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