Iodoethane → 1-Trityl-4-ethoxymethylpyrazole

HRID 570074

反応式

HRID 570074 の反応式
[C:1]([N:20]1[CH:24]=[C:23]([CH2:25][O:26][CH3:27])[CH:22]=[N:21]1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:28](N1C=C(CO)C=N1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[H-].[Na+].ICC.CC1C(CCOC)=C(C)N(C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)N=1>>[C:1]([N:20]1[CH:24]=[C:23]([CH2:25][O:26][CH2:27][CH3:28])[CH:22]=[N:21]1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参加物

6

反応物 5

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 10688521(1-Trityl-1H-pyrazol-4-yl)methanolHCID 685309021-Trityl-4-methoxymethylpyrazoleHCID 685310473,5-Dimethyl-4-methoxyethyl-1-tritylpyrazole

生成物 1

HCID 685285131-Trityl-4-ethoxymethylpyrazole収率 87%

実験手順

This compound is a slightly yellow solid and has been obtained as described in 2b for 1-trityl-4-methoxymethylpyrazole, starting from 1-trityl-4-hydroxymethylpyrazole (1.250 g; 3.67 mmol), sodium hydride (221 mg; 5.51 mmol) and iodoethane (1.5 mL; 18.35 mmol), as described in example 2a for 3,5-dimethyl-4-methoxyethyl-1-tritylpyrazole. Yield: 87% (1.174 g, 3.19 mmol).

後処理

  1. customhas been obtained

出典と根拠

ORDレコード
ord-bd1d11566e3c49478fb26a962eb4c24c
出典データセット
uspto-grants-2015_05
特許番号
US09023315B2

関連ノート

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