Hydrochloric Acid → 4-{3-Cyano-4-[2-(2-methoxyethoxy)phenyl]pyrrole-1-yl}-2-hydroxy benzoic acid

HRID 570843ノート

反応式

HRID 570843 の反応式
C([O:3][C:4](=[O:30])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH2:23][CH2:24][O:25][CH3:26])[C:13]([C:27]#[N:28])=[CH:12]2)=[CH:7][C:6]=1[OH:29])C.C(O)C.[OH-].[Li+].Cl>O.O1CCCC1>[C:27]([C:13]1[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[O:22][CH2:23][CH2:24][O:25][CH3:26])=[CH:15][N:11]([C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:30])=[O:3])=[C:6]([OH:29])[CH:7]=2)[CH:12]=1)#[N:28]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 3939Lithium HydroxideHCID 685064744-{3-Cyano-4-[2-(2-methoxyethoxy)phenyl]pyrrole-1-yl}-2-hydroxy benzoic acid ethyl ester

生成物 1

HCID 250521924-{3-Cyano-4-[2-(2-methoxyethoxy)phenyl]pyrrole-1-yl}-2-hydroxy benzoic acid収率 76.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-{3-cyano-4-[2-(2-methoxyethoxy)phenyl]pyrrole-1-yl}-2-hydroxy benzoic acid ethyl ester (0.072 g) in a mixed solvent of ethanol (9 mL) and tetrahydrofuran (3 mL) was added 1 mol/mL aqueous lithium hydroxide solution (2.7 mL), and this mixture was stirred at room temperature for 48 hours. This reaction mixture was poured into 1 mol/L hydrochloric acid (2.7 mL), and to this mixture was added water (30 mL). The precipitated solid was collected by filtration. This obtained solid was washed with water, dried under reduced pressure at 50° C. to give the title compound (0.051 g).

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. washThis obtained solid was washed with water
  3. customdried under reduced pressure at 50° C.

出典と根拠

ORDレコード
ord-a54a1c8fc3bb46fca5466b1a9772f379
出典データセット
uspto-grants-2015_05
特許番号
US09023882B2

反応ノート

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